Vortrag von Prof. Dr. Anthony J. Ricci (Stanford)
Anthony J. Ricci, Professor für Hals-Nasen-Ohren-Heilkunde an der Stanford University, hält am Montag, 28. September 2026, um 16.00 Uhr im Raum W04 1-162 einen Vortrag mit dem Titel „Voltage Dependent Hair Bundle Motion Provides Insight into how hair bundles are stimulated and support the hypothesis that underlying mechanics are consistent across species“.
Abstract:
Mammalian cochlea hair cell hair bundles are unique in their morphology and connectivity as
compared to those from other vertebrates like turtles and frogs. The hair bundles tend to have
three rows of stereocilia. Previous data demonstrated that unlike all other hair bundles tested
the stereocilia are not tightly coupled. Rather the stereocilia are coupled via viscoelastic
elements. In frog and turtle hair bundles depolarization results in a complex response consisting
of three distinct responses. The first was a fast steplike response toward the short end of the
hair bundle. This response was unaffected by MET channel blockers but disappeared with tip
link disruption. The second motion was 5-10x larger than the first component. This motion was
slower and moved toward the taller stereocilia. This second motion was blocked by MET
channel antagonists. The second motion was previously ascribed to slower adaptation
processes. The third motion was even slower than the second and again was toward the shorter
stereocilia. This motion became larger with larger depolarizations or with providing an offset to
the hair bundle. This motion was also antagonized by MET channel blockers. Surprisingly, similar
motions were found in mammalian inner hair cell hair bundles. The major difference was that
the second motion was an order of magnitude smaller, more comparable to that of the initial
step-like response. Even more surprisingly, a fourth motion was identified that was unmasked
by tip-link disruption. This motion was toward the tallest row of stereocilia and implies a
mechanical regulation likely based at the cuticular plate.
Der Vortrag wird organisiert von Prof. Dr. Jörg Albert und Dr. Thomas Effertz aus der Abteilung Sinnesphysiologie & Verhalten des Departments für Neurowissenschaften. Eine Anmeldung ist nicht erforderlich.
