RA 1: Genotypic and phenotypic measures for a generalized auditory profile

Hearing loss is widespread across the globe and differs markedly between individuals and over their life course. The primary aim of this research area is to address this diversity by developing a novel approach that connects deep genotyping with comprehensive phenotyping to advance the characterization of hearing loss and elucidate its etiology. To achieve this, we we are working on establishing a knowledge-based generalized auditory profile, which builds on comprehensive phenotypic audiological and targeted molecular data.

One focus is creating an entirely new molecular discovery pipeline that uses “humanized” fruit fly models carrying human disease genes for high-throughput molecular interaction analysis. These models will allow for detecting causative factors of human hearing loss and comorbidities, as well as developing novel biomarkers for diagnostic, predictive, and (gene-)therapeutic purposes.

Integrating data from multiple domains – including molecular, physiological, psychophysical, and cognitive assessments – into the generalized auditory profile will enable the comprehensive characterization of different types of hearing loss and their progression across the life course. This will not only help identify crucial clinical tipping points, but also facilitate a seamless transition between treatment options and devices.

By mapping individual longitudinal patient data to expert knowledge, auditory models, and cognitive and health factors, and linking these data to molecular profiles, we will realize the vision of predictive audiology that considers past and present hearing performance and predicts future outcomes.